The serum response factor coactivator myocardin is required for vascular smooth muscle development
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چکیده
منابع مشابه
The serum response factor coactivator myocardin is required for vascular smooth muscle development.
Formation of the vascular system requires differentiation and patterning of endothelial and smooth muscle cells (SMCs). Although much attention has focused on development of the vascular endothelial network, the mechanisms that control vascular SMC development are largely unknown. Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor, a ubiquitou...
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Myocardin is a muscle-restricted transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival. To identify myocardin-dependent functions in smooth muscle cells (SMCs) during postnatal development, mice harboring a SMC-restricted conditional, inducible Myocd null mutation were generated and characterized. Tamoxi...
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Myocardin is Differentially Required for the Development of Smooth Muscle Cells 1 and Cardiomyocytes 2 Mark H. Hoofnagle, Ronald L. Neppl, Erica L. Berzin, G.C. Teg Pipes, Eric N. 3 Olson, Brian W. Wamhoff, Avril V. Somlyo, Gary K. Owens. 4 5 Department of Molecular Physiology and Biological Physics, University of Virginia, 6 Charlottesville, VA 22908, USA 7 Robert M. Berne Cardiovascular Resea...
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Myocardin is a serum response factor (SRF) coactivator exclusively expressed in cardiomyocytes and smooth muscle cells (SMCs). However, there is highly controversial evidence as to whether myocardin is essential for normal differentiation of these cell types, and there are no data showing whether cardiac or SMC subtypes exhibit differential myocardin requirements during development. Results of ...
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Members of the myocardin-related family of transcription factors play critical roles in regulating vascular smooth muscle and cardiac differentiation. To examine the function of myocardin-related transcription factor (MRTF)-B, mice were generated from ES cells harboring a conditional insertional mutation, or gene trap, of the MRTF-B gene. Expression of the MRTF-B mutant allele results in a fusi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1233635100